The Collective Behavior and Conserved Microdomains of the HIV-1 Envelope Trimer Glycan Shield
Staff - Faculty of Informatics
Date: 24 May 2017 / 14:30 - 15:30
USI Lugano Campus, room A23, Red building (Via G. Buffi 13)
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Abstract: |
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The trimeric HIV-1-envelope (Env) spike is one of the most glycosylated protein complexes known, with roughly half its mass comprising host-derived N-linked glycan. Here we use molecular dynamics to provide insight into its structural dynamics and into how both protomer and glycan movements coordinate to shield the Env-protein surface. |
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Biography: |
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Thomas Lemmin is a postdoctoral researcher in the DeGrado Lab at the University of California, San Francisco (UCSF). His research principally focuses on combining molecular modeling and simulations with available experimental input in order to advance the understanding of mechanisms of complex biological systems and processes on a molecular scale. |
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